New Cancer Study Results are in.

Cysteine-rich protein reverses weight loss in lung cancer patients receiving chemotherapy or radiotherapy.

Tozer RG, Tai P, Falconer W, Ducruet T, Karabadjian A, Bounous G, Molson JH, Dröge W.

Hamilton Regional Cancer Centre, Hamilton, Ontario.

Cysteine-Rich Protein Prevents Weight Loss in Lung Cancer Patients:

A Promising Intervention Study

MONTREAL, Jan. 17, 2008 /PRNewswire-FirstCall/ - Immunotec Inc. (TSX-V: IMM) announced today the successful completion of a multi-center randomized, double-blind clinical trial on cancer-related weight loss (cachexia) in lung cancer patients which was performed in collaboration with various Canadian clinical centers (x) . The research concluded that patients treated with IMN 1207 showed significant increases in body weight (Tozer et al.Antioxidants & Redox Signaling (2008) 10:395-402). Immunotec also announced the initiation of a follow-up study to confirm the positive results.

The massive loss of body weight and muscle mass in advanced cancer patients is typically associated with psychological stress, financial burden and a decreased quality of life. Until now there have been no dietary interventions known to satisfactorily prevent this process.

Immunotec's new study included 66 patients with advanced lung cancer receiving state of the art chemotherapy or radiotherapy. The patients had already suffered significant involuntary weight- loss prior to treatment. During a six month treatment period the patients were given either casein, a protein supplement low in cysteine which is widely used in clinical nutrition ("placebo") or IMN 1207, a specially-prepared glutathione enhancing cysteine-rich whey protein isolate supplied by Immunotec Inc. The results showed that patients in the placebo group continued to lose weight whereas patients treated with IMN 1207 showed a significant increase in body weight. Incidentally, these patients also showed an increase in strength and quality of life parameters. This study showed for the first time that cancer-related weight loss (cachexia) can be prevented by a single source of protein. Dr. Gerald Batist, Chair, Department of Oncology, McGill University stated "Having been involved in the early mechanistic studies of the therapeutic use of whey proteins, I'm pleased to see this particular formulation being tested in the clinic. The data to date encourage additional and expanded clinical trials". Dr. Wulf Droge, Senior Vice-President Research & Development at Immunotec Inc. emphasized that the results of this first trial should be viewed with cautious optimism. A second trial has been initiated to confirm the results.

Among other questions, this clinical trial also addressed the controversy about antioxidant use in chemotherapy. Since radiotherapy and many types of chemotherapy work by raising levels of oxidative stress and free radical formation to destroy cancer cells, oncologists have voiced concern that treatment of the patient with antioxidants may "protect" the cancer from the toxic effects of the therapy. If this were the case, antioxidants could even be expected to shorten the life span of the patients. Immunotec's study now showed that this was clearly not the case with IMN 1207. Based on his earlier work at his laboratory at the National Cancer Research Center of Germany (DKFZ) in Heidelberg, Dr. Droge was reasonably confident that supplementation with a critical precursor of the major cellular antioxidant glutathione, would actually improve the condition of the patients, most probably by ameliorating adverse effects of these therapies on the patients' healthy tissues. The results of this new study suggest that this is true. The antioxidant glutathione is distinct from other antioxidants including the popular antioxidant vitamins A, C, and E which are widely used as nutritional supplements. Glutathione is involved in the removal of reactive oxygen species and other potential toxic compounds through special biochemical processes and can reach relatively high and beneficial concentrations in cells and tissues depending on the availability of its biosynthetic precursor cysteine.

About IMN 1207 from Immunotec Research (Immunocal plus)

IMN 1207 is a cysteine-rich protein. It is the research formulation of the undenatured whey protein Immunocal(R)/HMS 90(R), a dietary natural health supplement, developed and marketed worldwide by Immunotec during the past 12 years. Immunocal(R)/HMS 90 is a precursor of the major cellular antioxidant glutathione, an element important in maintaining a strong

immune system.

About Immunotec Inc.

Immunotec is engaged primarily in the development and marketing of natural health products, dietary supplements, food, vitamins and personal care products, many of which are manufactured on its behalf by third parties. Immunotec's products are distributed and sold in Canada and the United States through a network marketing system and in other countries through exclusive distributorship agreements. Immunotec's investment in this study is another manifestation of its ongoing commitment to research and development. http://www.immunotec.com.

x Montreal General Hospital (McGill University teaching hospital) Montreal , Quebec , Canada

x Cross Cancer Institute, Alberta Cancer Board (University of Alberta affiliate) Edmonton , Alberta Canada

x Jewish General Hospital (McGill University teaching hospital) Montreal Quebec,Canada

x Juravinski Cancer Centre (McMaster University and Hamilton Health Sciences affiliate) Hamilton , Ontario,Canada .

x Allan Blair Cancer Centre (a division of Saskatchewan Cancer Foundation) Regina , Saskatchewan , Canada .

PMID: 18158761 [PubMed - in process]

See the actual report:

http://www.liebertonline.com/doi/pdfplus/10.1089/ars.2007.1919

For more information on Immunocal go to www.3MinuteDecision.com/dharnaha

Natural Treatment for Gout

Montmorency Tart Cherry

Not only are Montmorency tart cherries high in melatonin which is a natural Glutathione Booster, but they are Good for Gout too.

Gout is a form of arthritis that is caused by the build-up of a substance found in the body called uric acid. This acid is used by the body to break down a common substance in many different foods known as purines.

When people suffer from gout, the uric acid that has built up in their system begins to form jagged crystal-like formations in the blood stream. It is these painful little crystals that cause the horrible swelling and pain that gout is known for. But what causes the uric acid build up and how do you know if you're having a gout attack?

The causes of gout attacks can be attributed to many different things. Foods high in purines are a common culprit. Things like salmon, seafood and alcohol. Also, offal meats (parts of animals we eat other than muscle, like liver and kidney's) are suspected of causing gout because of their high purine content.

For reasons unknown to doctors, about 75% of gout sufferers' first start to feel an attack in the joint of the big toe. Other likely joints that might signal a gout attack are the ankle, knee or elbow.

The pain associated with gout comes from two different sources. There is the sharp, stabbing pain caused by the crystals that get caught in the toe joint, as well as the pain caused by the swelling and inflammation of the tissues around the joint.

Gout has four stages that a sufferer could end up going through if the condition is left untreated. The first is asymptomatic, which simply features rising levels of the sinister uric acid rising in the blood stream, but before any symptoms manifest.

The second is acute gout, which features a person's first gout attack, most of which go away quickly and there isn't a frequent reoccurrence. Remember, the sooner you get treatment, the sooner the pain will go away. The average case of gout lasts only a day or two with proper care.

The third stage of gout is intercritical, which is just the symptom-free time between attacks, and the fourth and final stage of gout is the chronic stage. Chronic gout is made up of multiple bouts of the disease and the gout attacking more than one joint at once.

If gout isn't treated properly, serious health problems can arise, such as kidney damage and the formation of kidney stones, as well as hypertension (high blood pressure).

While there is no "cure" for gout in the traditional sense, since the disease can return anytime there is an imbalance in your body's uric acid levels, there are many different treatments and you can effectively eliminate the risk of gout through natural means.

Most doctors prescribe a change in diet from foods high in purine to foods that help the body absorb excess uric acid in the blood stream. Most berries and fruit are great at absorbing uric acid, whereas foods high in protein, such as chicken or even tofu should not be eaten at all during a flare up since it is believed those foods make matters worse.

In conclusion, even though gout is associated with a period in history long gone when knights on horseback were busy saving fair maidens, it is very much an ailment of today's world. But with the proper diet and early diagnosis, the horrible pain of gout can be controlled.

To learn more take a video tour at 3 Minute Decision.

More on Detoxification

Glutathione and Detoxification

The glutathione system is the body's primary detoxification mechanism and, as such, is responsible for the removal of toxic compounds from the body, regardless of their etiology. Heavy metals, pharmaceuticals, insecticides, cigarette toxins, air and water pollutants - just to name a few. If your body's intracellular glutathione level is not optimized, it logically follows that cellular damage will result. The cumulative damage caused by the relentless onslaught of environmental toxins defines the very process of aging and disease.

The following abstracts contain overviews of studies performed that demonstrate glutathione's role in detoxification. Click on the corresponding link (blue) to read the abstract as found on the National Institute of Health's government website:

Cysteine metabolism and metal toxicity
Quig D. [Altern Med Rev 1998 Aug;3(4):262-70] The pro-oxidative effects of metals are compounded by the fact that the metals also inhibit antioxidative enzymes and deplete intracellular glutathione. Cysteine has a pivotal role in inducible, endogenous detoxication mechanisms in the body, and metal exposure taxes cysteine status. Basic research pertaining to the transport of toxic metals into the brain is summarized, and a case is made for the use of hydrolyzed whey protein to support metal detoxification and neurological function. Early detection and treatment of metal burden is important for successful detoxification, and optimization of nutritional status is paramount to the prevention and treatment of metal toxicity.

Mechanism of action and value of N- acetylcysteine in the treatment of early and late acetaminophen poisoning: A critical review.
Jones AL. [Journal of Toxicology -- Clinical Toxicology. 1998; volume 36, number 4, pages 277-285] The mechanism of action of N-acetylcysteine in early acetaminophen poisoning is well understood, but much remains to be learned of the mechanism of its possible benefit in acetaminophen poisoning presenting beyond 15 hours. Candidate mechanisms for a beneficial effect in-clude improvement of liver blood flow, glutathione replenishment, modification of cytokine production, and free radical or oxygen scavenging.

Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity.
Lauterburg BH and Velez ME. [Gut. 1998; volume 29, pages 1153-1157]. "The data indicate that low glutathione may be a risk factor for [acetaminophen] hepatotoxicity in alcoholics because a lower dose of [acetaminophen] will be necessary to deplete glutathione below the critical threshold concentration where hepatocellular necrosis starts to occur."

Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system.
Husain K, Scott BR, Reddy SK, Somani SM. [Alcohol. 2001 Oct;25(2):89-97.] This study was undertaken to examine the interactive effects of chronic ethanol and nicotine consumption on the antioxidant defense system in different tissues of rat. Chronic ingestion of ethanol resulted in a significant depletion of glutathione (GSH) content in liver, lung, and testes, whereas chronic administration of nicotine significantly depleted GSH content in liver and testes. The combination of ethanol plus nicotine resulted in a significant depletion of GSH content in liver, lung, and testes. Chronic ingestion of ethanol resulted in a significant decrease in glutathione peroxidase (GSH-Px) activity in liver and kidney, whereas a combination of ethanol plus nicotine increased GSH-Px activity in liver and decreased GSH-Px activity in kidney and testes. Ethanol, nicotine, or a combination of ethanol plus nicotine significantly increased lipid peroxidation, respectively, in liver. It is suggested that prolonged exposure to ethanol and nicotine produce similar, and in some cases additive, oxidative tissue injuries in rat.

Treatment of sulfur mustard (HD)-induced lung injury.
Anderson DR, Byers SL, Vesely KR. [J Appl Toxicol 2000 Dec;20(S1):S129-S132] An in vivo sulfur mustard (HD) vapor exposure model followed by bronchoalveolar lavage was developed previously in this laboratory to study biochemical indicators of HD-induced lung injury. This model was used to test two treatment compounds-niacinamide (NIA) and N-acetyl cysteine (NAC)-for their ability to ameliorate HD-induced biochemical changes. These results show that NAC may be useful as a potential treatment compound for HD-induced lung injury.

Role of glutathione redox cycle and catalase in defense against oxidative stress induced by endosulfan in adrenocortical cells of rainbow trout (Oncorhynchus mykiss).
Dorval J, Hontela A. [Toxicol Appl Pharmacol. 2003 Oct 15;192(2):191-200.]
The role of antioxidants in maintaining the functional integrity of adrenocortical cells during in vitro exposure to endosulfan, an organochlorine pesticide, was investigated in rainbow trout (Oncorhynchus mykiss). ...protection against the adrenal toxicity of endosulfan, a pesticide that impairs cell viabilityand cortisol secretion. CAT, GPx, and GSH were identified as important antioxidants in maintaining the function and integrity of rainbow trout adrenocortical cells and ATA, L-BSO, and NAC were identified as effective modulators of CAT and GSH redox cycle. Moreover, this study suggests that the glutathione redox cycle may be more efficient than catalase in protecting adrenocortical cells against endosulfan-induced oxidative stress.

Toxic metals and antioxidants: Part II. The role of antioxidants in arsenic and cadmium toxicity
Patrick L. [Altern Med Rev. 2003 May;8(2):106-28.] Exposure to toxic metals has become an increasingly recognized source of illness worldwide. Both cadmium and arsenic are ubiquitous in the environment, and exposure through food and water as well as occupational sources can contribute to a well-defined spectrum of disease. The mechanisms of arsenic- and cadmium-induced damage include the production of free radicals that alter mitochondrial activity and genetic information. The metabolism and excretion of these heavy metals depend on the presence of antioxidants and thiols that aid arsenic methylation and both arsenic and cadmium metallothionein-binding. S-adenosylmethionine, lipoic acid, glutathione, selenium, zinc, N-acetylcysteine (NAC), methionine, cysteine, alpha-tocopherol, and ascorbic acid have specific roles in the mitigation of heavy metal toxicity. Several antioxidants including NAC, zinc, methionine, and cysteine, when used in conjunction with standard chelating agents, can improve the mobilization and excretion of arsenic and cadmium.

To Learn more about Glutathione, Immunocal, and Immunotec just click here.

The Science of Glutathione

A New Outlook on Life’s Health Challenges
Let’s face it, most of us live a fast-paced lifestyle that is very demanding on our health. The habit of reacting only once the body breaks down is giving way to the realization that prevention can be the best medicine.

Glutathione is emerging as one of the keys to the health puzzle. It was the discovery of glutathione’s importance in optimizing your body’s first line of defense – your immune system – that led to the development of a whey product that raises intracellular glutathione.

Glutathione: The Next Household Word
You may or may not have heard of glutathione, even though over tens of thousands of medical articles have highlighted its importance. Optimizing glutathione levels will shortly join the list of factors known by everyone to have an impact on our health and well-being, along with vitamin supplementation and cholesterol regulation.
Glutathione is a small protein produced naturally in every cell of our body. It is made up of three protein building blocks, called amino acids. These are glutamic acid, cysteine and glycine. The cysteine amino acid contains a sulfur group responsible for the chemical properties of the whole glutathione protein.

Glutathione: An Essential Health AID
There are three major roles of glutathione in the body: Antioxidant, Immune booster, and Detoxifier. Even cells in the healthiest of individuals constantly need to replenish their glutathione supply.

The Master Antioxidant (AID)
Antioxidants participate directly in the destruction of reactive oxygen compounds called free radicals. These by-products of a cell’s normal function can’t be avoided, but exposure to ultraviolet radiation from the sun or other sources promotes their emergence. Free radicals have been linked to muscle fatigue during exercise and aging.

For this reason, the body is equipped with a variety of antioxidants. Vitamins C and E are natural antioxidants but do not occur naturally in the body. These and other antioxidants actually depend on glutathione to function properly, which is why glutathione is called “the Master Antioxidant”.

Food for the Immune System (AID)
Glutathione helps build your immune system’s resistance and improve your chances of staying healthy.

Lymphocytes are cells of your immune system. Glutathione is essential for lymphocytes to increase in number, produce antibodies, and function efficiently.

A Natural Detoxifier (AID)
Our food and water sources are becoming increasingly contaminated with chemicals, as is the air that we breathe. Supplemental detoxifiers such as glutathione help to counter the effects of the toxins we inhale and ingest.

By physically binding to toxic compounds in cells, glutathione helps make them soluble - and harmless. The body can then eliminate these disarmed toxins in the bile and urine.

Raise Glutathione Levels—But How?
The fact is, you can’t ingest glutathione to feed it to your cells. Glutathione must be manufactured within your cells. What you can do is help this natural process by giving your body the glutathione building blocks it needs. The limiting factor in your daily intake of building blocks is the amino acid cysteine.

Cysteine, traveling alone as an amino acid through our digestive system, is poorly absorbed and very little of it will actually make the trip from our mouths to our cells. Luckily, when cysteine molecules bind to each other to travel in pairs, they can survive this process. They do this by forming a bond between sulfur molecules. These bonded cysteine amino acids are then called ‘cystine’. Although this sulfur bond is resistant to the digestive process, it is easily broken if submitted to heat or mechanical stress.

Immunocal’s Unique Manufacturing Process
Before Dr. Bounous and his colleagues devised the technique used to produce Immunocal, the scientific community was unsuccessful at producing a supplement rich in active bonded cysteine.

Immunocal is a highly purified protein powder isolated from whey (milk serum). Immunocal’s secret lies in its proprietary manufacturing process that guarantees:

• The most natural of products isolated in the most natural of conditions.
• A protein source that remains active, which is accomplished by maintaining the fragile, precious bond between cysteine amino acids.
• An even distribution of active protein throughout the product, for the same efficacy inevery serving.

Raise Glutathione Levels - Safely and Naturally
There are other synthetic ways in which glutathione levels may be raised. However, the high level of side effects limits their long-term use. In contrast, Immunocal is just as effective and has no known side effects when used as directed. It contains natural proteins isolated from milk, but a negligible amount of lactose; therefore, even lactose - intolerant individuals can use it safely.

Immunocal: Feeding Bonded Cysteine to Cells
Numerous clinical studies have been performed, using the highest standard of scientific design, to prove Immunocal’s efficacy and reliability. In one such study, Immunocal was proven to raise glutathione levels by 35.5% in lymphocytes.

What’s more, testimonial evidence from thousands of satisfied customers in a dozen countries confirms what science was able to prove: Immunocal works!

*The Effect of Supplementation with a Cysteine Donor on Muscular Performance
Published in the Journal of Applied Physiology, 87: 1381-1385, 1999
by LC Lands, MD, PhD*Ü, VL Grey, PhD܇, AA Smountas, BSc*
*Division of Respiratory Medicine, ÜDepartment of Pediatrics, ‡Department of
Biochemistry, McGill University Health Centre - Montreal Children’s Hospital,
Montreal, Quebec, Canada

This study was conducted in healthy adults for 3 months using the highest standard of scientific design (peer-reviewed, double-blind, randomized, prospective and placebo-controlled study) to ensure validity of the results. Statistical calculations were performed to analyze the results.

Praise and Recognition From the Past and Present
Immunotec Research Ltd., is a research organization first and foremost and as such, is dedicated to marketing products that have received the highest approval from the scientific community. Immunocal is no exception.

Scientists have shown their support for Immunocal in many ways through the years, from its inception to its introduction to the North American market in 1996:

• Immunocal is patent-protected worldwide
• Immunocal is also listed in the U.S. Physicians’ Desk Reference and the Pharmacist’s Red Book
• Immunocal joins a select group of nutritional products qualifying for reimbursement coverage under Medicare/Medicaid in the United States

For a Video Overview on the Immunocal and Immunotec click here.

Presentation about Immunocal on FDA website

The product validation includes a presentation from the FDA website. It references Undenatured Whey Protein Isolate (Immunocal).

Have a look at the presentation.

Get Rid of your Stress

PNT 200 wins bronze at Health Ingredients Europe

Unique peptide is recognized for its calming properties

Those who have discovered PNT 200 know that it is a great way to help relieve the symptoms of stress. And the Health Ingredients (Hi) Europe committee is equally impressed, having recently recognized the effectiveness of its active ingredient with a bronze medal at the 2004 Hi Europe Innovation Awards!

How was this unique peptide discovered? After 12 years of research, in partnership with Université Henri Poincaré-Nancy in France, a peptide was found with relaxing properties within a milk protein hydrolysate. The research stemmed from the observation of the calm state of a baby after drinking milk, prompting researchers to investigate the relationship between milk consumption and any calming effect resulting from it. This led to the use of a well-known digestive enzyme to develop the patented milk casein hydrolysate found in PNT 200.

This discovery was significant, given the amount of stress that people face each and every day. According to the World Health Organization (WHO), nearly 450 million people worldwide are
affected by stress-related disorders. Although high, this number is not surprising when we consider that life is filled with noise, social pressures, pollution and a myriad of other stressors
that infiltrate our minds and bodies.

Despite its negative connotation, stress is a perfectly natural and healthy physiological reaction that is necessary to prepare us to act quickly and efficiently in certain situations; it also allows us to adapt to changing needs and situations. It becomes a negative force when we experience too much stress or are unable to get reprieve from tension - this is when management techniques and products to help lessen the effects of stress come into play.

PNT 200 is perfectly positioned for today’s fast-paced life and the recognition of its active ingredient is an important milestone for the product. The Health Ingredients award further substantiates its value and the science that it is based on. PNT 200 is the natural alternative for those who are looking to better manage the stresses of everyday life.

For more information on PNT 200 click here.

Summary of Medical Publications on Immunocal/HMS 90

As I mentioned in my last blog, and as unscrupulous as it may sound, there are some companies out there that sell products that proclaim to raise intracellular Glutathione without having done their "homework".

Due to the extensive research done by Dr. Gustavo Bounous - co-founder of Immunotec, invariably they will reveal that their product is based upon OUR research. Our research is the reason why we have 10 Method of Use patents (our product does what we say it does).

Always do your Due Diligence and ask to see their research using their product.

Here's some of ours...........

Bounous G., Molson J.

Competition For Glutathione Precursors Between The Immune System And The Skeletal Muscle: Pathogenesis Of Chronic Fatigue Syndrome.

Med Hypotheses. 1999 Oct;53(4) :347-349.

Kennedy R.S., Konok G.P., Bounous G., Baruchel S., Lee T.D.

The Use Of A Whey Protein Concentrate In The Treatment Of Patients With Metastatic Carcinoma : A Phase I-II Clinical Study.

Anticancer Res. 1995 Nov-Dec;15(6B) :2643-2650.

Bounous G., Baruchel S., Falutz J., Gold P.

Whey Proteins As A Food Supplement In HIV-Seropositive Individuals.

Clin Invest Med. 1993 Jun;16(3) :204-209.

Bounous G., Gold P.

The Biological Activity Of Undenatured Dietary Whey Proteins : Role Of Glutathione.

Clin Invest Mod. 1991 Aug;14(4) :296-309.

Bounous G., Batist G., Gold P.

Whey Proteins In Cancer Prevention.

Cancer Lett. 1991 May 1;57(2) :91-94. Review Letter.

Papenburg R., Bounous G., Fleiszer D., Gold P.

Dietary Milk Proteins Inhibit The Development Of Dimethylhydrazine-Induced Malignancy.

Tumour Biol. 1990;11(3) :129-136.

Bounous G., Gervais F., Amer V., Batist G., Gold P.

The Influence Of Dietary Whey Protein On Tissue Glutathione And The Diseases Of Aging.

Clin Invest Med. 1989 Dec;12(6) :343-349.

Bounous G., Batist G., Gold P.

Immunoenhancing Property Of Dietary Whey Protein In Mice: Role Of Glutathione.

Clin Invest Med. 1989 Jun;12(3) :154-161.

Bounous G., Kongshavn P.A., Gold P.

The Immunoenhancing Property Of Dietary Whey Protein Concentrate.

Clin Invest Med. 1988 Aug;11(4) :271-278.

Bounous G., Papenburg R., Kongshavn P.A., Gold P., Fleiszer D.

Dietary Whey Protein Inhibits The Development Of Dimethylhydrazine Induced Malignancy.

Clin Invest Med. 1988 Jun;11(3) :213-217.

Bounous G., Shenouda N., Kongshavn P.A., Osmond D.G.

Mechanism Of Altered B-Cell Response Induced By Changes In Dietary Protein Type In Mice.

J Nutr. 1985 Nov;115(11) :1409-1417.

Bounous G., Kongshav.n. PA.

Differential Effect Of Dietary Protein Type On The B-Cell And T-Cell Immune Responses In Mice.

J Nutr. 1985 Nov;115(11) :1403-1408.

Bounous G., Letourneau L., Kongshavn P.A.

Influence Of Dietary Protein Type On The Immune System Of Mice.

J Nutr. 1983 Jul;113(7) :1415-1421.

Costantino A.M., Balzola F., Bounous G.

Changes in biliary secretory immunoglobulins A in mice fed whey proteins.

Minerva Dietol Gastroenterol 1989 35(4): 241-5

Baruchel S., Bounous G., Gold P.

Place For An Antioxidant Therapy In Human Immunodeficiency Virus (HIV) Infection.

Oxidative Stress, Cell Activation and Viral Infection – C. Pasquier et al. (eds) 1994; 311-321.

Bounous G., Kongshavn P.A.

Influence Of Dietary Proteins On The Immune System Of Mice.

J Nutr. 1982 Sep; 112(9) :1747-55.

Bounous G., Stevenson M.M., Kongshavn P.A.

Influence Of Dietary Lactalbumin Hydrolysate On The Immune System Of Mice And Resistance To Salmonellosis.

J Infect Dis. 1981 Sep; 144(3) :281. No abstract available.

Lands L.C., Grey V.L., Smountas A.A.

Effect Of Supplementation With A Cysteine Donor On Muscular Performance.

J Appl Physiol. 1999 Oct;87(4) :1381-1385.

Lothian B., Grey V., Kimoff R.J., Lands L.C.

Treatment Of Obstructive Airway Disease With A Cysteine Donor Protein Supplement: A Case Report. Chest. 2000 Mar;117(3) :914-6.

Watanabe A., Higuchi K., Okada K., Shimizu Y., Kondo Y., Kohri H.

Treatment Of Chronic Hepatitis Using Whey Protein (Non-Heated)

16^th International Congress of Nutrition (Montreal, Canada 1997).

Bounous G.

Whey Protein Concentrate (WPC) And Glutathione Modulation In Cancer Treatment.

Anticancer Research 20 :4785-4792 (2000)

Tsai W.Y., Chang W.H., Chen C.H., Lu F.J.

Enhancing Effect Of Patented Whey Protein Isolate (ImmunocalÔ) On The Cytotoxicity Of Anti-Cancer Drug.

Nutrition and Cancer, Vol 38, Issue #2.

Baruchel S., Viau G., Olivier R., Bounous G., Wainberg M.A.

Nutriceutical Modulation Of Glutathione With A Humanized Native Milk Serum Protein Isolate, ImmunocalÔ : Application In AIDS And Cancer.

Marcel Dekker Inc. – New York – Basel – Hong Kong

BOUNOUS G., MOLSON J.

The Antioxidant System

Anticancer Research 23: 1411-1416 (2003)

Bartfay WJ, Davis MT, Medves JM, Lugowski S

Milk Whey Protein decreases Oxygen Free Radical Production in a Murine Model of Chronic Iron-Overload Cardiomyopathy

Can J. Cardiol Vol 19 No 10, Sept. 03: 1163-1168 (2003)

Bounous G., Beer D.

Molecular Pathogenesis and Prevention of Prostate Cancer

Anticancer Research 24: 553-554 (2004)

GREY V., MOHAMMED S.R., SMOUNTAS A.A., BAHLOOL R., LANDS L.C.

Improved Glutathione Status in Young Adult Patients with Cystic Fibrosis Supplemented with Whey Protein

Journal of Cystic Fibrosis, Vol. 2, Issue 4, (2003)

BAUMANN J.M., RUNDELL K.W., EVANS T.M., LEVINE A.M.

Effects of Cysteine Donor Supplementation on Exercise-Induced Bronchoconstriction

Med. Sci. sports Exerc., Vol. 37, No. 9, pp1468-1473, (2005).

dröge w.

Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?

Phil. Trans. R. Soc. B., Vol. 360, 2355-2372, (2005)

Patents Make a Difference

Some products on the market today promote themselves using the research of other companies. It is easy for a company to get a Composition Patent. Basically, submit your "recipe" for your product and you can claim that your product is patented. But what does that really mean to me and you?

Method of Use patents on the other hand, are Very Different. In order to get this type of patent you need to complete double blind studies (using your product), peer reviewed papers, needs to be renewed annually and on an on.

Immunocal has 10 Method of Use patents.

To see the U.S. and Canadian patents, click on the links below.

United States: 5,888,552, 5,451,412, 5,230,902, 5,456,924, 5,290,571, 5,846,939

Canada: 2,142,277 2,090,186 1,333,471 1,338,682

Immunocal and Autism

There is a ton of anecdotal evidence that raising Glutathione helps with Autism over the years. In fact there is a study at University of Texas Southwestern Medical Center in Dallas. It has been so successful that it is now entering Phase II studies. Here is the original press release:

Immunotec Research Ltd., Leading Canadian Nutraceutical
Company, Initiates U.S. Autism Research Project

MONTREAL, November 22, 2006--- Scientists at the University of Texas Southwestern Medical Center in Dallas have started a study in which a specially formulated whey protein isolate(Immunocal) will be used to raise glutathione levels in an attempt to lessen symptoms of autism.

Autism is a neurological developmental disorder that affects children’s ability to socialize normally, impairs language skills, restricts their interests and curiosity and causes other behavioral abnormalities. Most cases are diagnosed before three years of age, and there has been an alarming increase in the number of cases diagnosed over the past two decades. Currently, 1 in every 175 American children is being identified as having autism, and these numbers are on the rise each year.

To date, medical treatment of this disorder has been minimally effective. Although the causes of autism have not been clearly identified, research has suggested that chronic biochemical imbalance plays a role. Studies have shown that levels of the major intracellular antioxidant “Glutathione” is typically about 50% lower in children with autism. Glutathione, which is
produced by every cell in the body, is responsible for a number of functions including removing or neutralizing dangerous substances that we are exposed to on a daily basis, including toxic metals. Toxins, pollution, disease, stress, and poor diet can all contribute to loss of glutathione. When glutathione levels reach a critically low degree, we are much more vulnerable to toxins and immune dysfunction.

Principal investigator for this study is Dr. Janet Kern, an adjunct assistant professor of psychiatry at UT Southwestern, which is internationally recognized for its clinical and research programs. “Some children with autism are poor detoxifiers relative to normally developing children, and in particular, have trouble excreting toxic metals,” said Dr. Kern. “Toxic metals that are not eliminated may build up in the brain. Plasma glutathione has been found to be lower in children with autism, particularly, in children with autism who have regressed. We want to clearly establish that raising glutathione levels in these children will improve their ability to detoxify these substances and in that way improve some of their symptoms.”

Dr. Jill James, Professor of Pediatrics at University of Arkansas for Medical Sciences, will be a coinvestigator. Dr. James is noted for her landmark studies in autism and toxicology and is among the first scientists to point out the links with low glutathione levels. “We know that Immunocal has been used to raise glutathione in other studies very effectively in areas such as cancer and lung disease. We want to take advantage of this same technology”, stated James.

For more information go to www.gsh-booster.com

Just Learning to Blog

As a beginner blogger is helps to look at other peoples work for inspiration.

Colin is the author of many blogs; Golden eBooks for Newbies, Search Engine Optimization and Traffic Tips, Free PC Security. MySpace Blog, Safety Tips for Newbies, Golden eBooks Blog, 6 Ways to Make Money at Home, Top Affiliate Tactics, Life. He has presented the Be The Blog award and Best Blogging Buddies award to the following:

0-Cotojo 1-Lisa , 2-Kim, 3-Deborah, 4-Pearl, 5-Sandy, 6-Jesse, 7-Chris, 8- Colin 9-Santa, 10-Blog Elf, 11-Jackie, 12-Marzie, 13-Adrian, 14-Jos, 15-NAFA SG, 16-Paula, 17-Sue, 18-Kathy 19-Maartje, 20-Morgan, 21-Greg, 22-MaryAnn, 23-Eric, 24-Hawk, 25-Carol, 26-Diane, 27-Ev Nucci, 28-Surjit, 29-Kuanyin, 30-Christy Z, 31-Sandee, 32-Robin, 33-Hanna, 34-Maunie, 35-Kim, 36-Bobby, 37-Billy, 38-David, 39-Jennifer, 40-Aryst, 41-Winston, 42-Christy, 43-LilyRuth, 44-Jess, 45-Rudy, 46-Lynda, 47-Lili, 48-Sandy G, 49-Ange, 50-BlackWyrm, 51-Vincent, 52-Colin & Anne, 53-Blandly Urbane, 54-Marco, 55-Mihaela Lica, 56-John C, 57-Aziz-sm, 58-Ugyen, 59-Lansy, 60-Alex Badalic, 61-Victors, 62-Nostalgia Manila, 63-Franco Yong, 64-Herby, 65-Rubie, 66-Santaram & BVK, 67-Jean-david, 68-Namgay, 69-Catherine, 70-Yunita P, 71-Debbie Dolphin, 72-Lorimer Black, 73-Dream Catcher, 74-Fred Plimley, 75-Anja Merret,76-Maria Lourdes, 77-Jon B, 78-Aayush, 79-Denise, 80-Dharmendra P, 81-Brent D, 82-Jerry & Daryl McCoy, 83-Brian B, 84-Calvin Innes, 85-Pieter Marburn, 86-Jessica Field, 87-Taflas, 88-Alex Sysoef, 89-Norie, 90-Justin Stanley, 91-Ashish, 92-David Ledoux, 93-Thanate Tan, 94-Kevin, 95-Etienne, 96-Gerbera, 97-Christina, 98-Abhishek d, 99-Uprai, 100-Texas_Jam, 101-Azmiel, 102-Daniel, 103-Kristin B, 104-Luwis, 105-Adavait, 106-Now Sourcing, 107-Buen Amigo, 108-Kiran Pande, 109-Peterson Wong, 110-Lynn, 111-Chessnoid, 112-Luis Hipolito, 113-Joliveira, 114-Jennifer & Pete, 115-Team Dog, 116-Megan, 117-Mark, 118-Raivyn, 119-Mel, 120-Andrea, 121-Jen / domestika, 122-Mimi, 123-Bobo, 124-Lynda Lehmann, 125-Dread Bob, 126-Julie, 127-RennyBA, 128-Bobbarama, 129-Becky, 130-Magdalena, 131-Michelle, 132-Stacie, 133-Climate of Our Future Team, 134-CashMarble, 135-OilOffShoreMarine, 136-Jos Additional BlogLove, 137-Piper, 138-Barbara, 139-Ann Clemmons, 140-Deb, 141-madang.com, 142-RamblingMoo.com, 143-blogginginmypyjamas, 144-StylewithPassion, 145-Chinneeq, 146-Dora-zooropazoo, 147-Babyshern, 148-HiPnCooLMoMMa 149-Rachel’s Soulful Thoughts 150-When Silence Speaks, 151-Dancing in Midlife Tune, 152-Underneath it All, 153- I am Dzoi, 154-Hobbies and Such, 155-moms…..check nyo, 156-Choc Mint Girl, 157-Amel’s Realm, 158- My Thoughts, 159-Rusin Roundup, 160-Juliana’s Site, 161-Max, 162-Rooms of My Heart, 163-A Great Pleasure, 164-LadyJava’s Lounge, 165-Jesie, 166-Steven, 167-Trinity, 168-Leena, 169-Nick, 170-Nessa, 171-Debbie Dolphin, 172- Anna t, 173-krrey_boo, 174-Logic, 175-Steve Ho, 176-Virtual Entrepreneur, 177-WalksFarWoman, 178-Anna, Beth & Cory’s Mom, 179-Toon, 180-Belinda 181-EPSpeaks, 182-Teacher Julie 183-jafajfer, 184-pmonchet, 185-Aslan, 186-arouetvoltaire , 187-Tanny, 188-Il vaso di Pandora, 189-Non Lineare, 190-Omniamundamundis, 191-LineaNeuronica, 192-Semplicemente Lisa 193-la penna che graffia 194-Angelbaby, 195-Divya, 196-Cyn, 197-Donna, 198-Liudmila, 199-djeblog, 200-Gracie Belle, 201-Reverend Ray, 202-Walter Winstuff, 203-Denny, 204-Terry (mee mOe), 205-awannabe, 206-Z.S., 207-Il Gnagnera, 208-Kevin Grieves, 209-DatCurious, 210-DatMoney, 211-Sanni, 212-Rolando’s Quiet Space, 213-SatoNa ,214-Levian , 215-21Knots, 216-PuTLie,217-Riciard’s, 218-Darlene, 219-Rantings of a Woman,220-La Place de Cherie , 221-Enjoying The Ride, 222-A Window To Our World,223-Juliana, 224-Retchel’s Pure Life, 225-We Are Family,226-Yesterday, Today and Tomorrow, 227-Echoes of Life, 228-My 3 Boys and I,229-Mammagatta, 230-Juliana’s Lair, 231-Bless Sanctuary,232-Confessions of An Army Wife , 233-Jean’s my So-called Life, 234-So cute tiny pixels,235-Denz Techtronics Blog, 236-Wanna Be On Top!, 237-Carpe Diem,238-My so-called Life, 239-TEEBOB, 240-Kikay,241-Alaverde33, 242-CC’s Lifestyles and Reviews, 243-Pinay’s Lifestyles,244-Yesterday, Today and Tomorrow, 245-The Creativity Of Me, 246-OzLife247-Scattered Thoughts of Mine, 248-Another Journal of Mine, 249-My Drama,250-By The Way, 251-Paul, Toni and Lance - Bridging the Distance, 252-Live Love Pink,253-In The Lance’s Mind, 254-My Life, 255-Rants and Ramblings,256-WorldBlog, 257-Our Journey to Life, 258-Simply the best,259-Paul and Toni, 260-Alpha’s Blog, 261-because life is fun,262-The Simple Life of a Baghag, 264-Sweet Lullaby, 265-AnitoKid, 266- Lisa WAHM, 267-Ben Spark268-Kesa, 269-Mauro, 270-Sindi271-Alianorah, 272-Jennie, 273-CTN,274-Jeremy, 275-Polliwog’s Pond, 276-Yvette,277-Ali (DorisDay), 278-Rodney, 279-Alice, 280- WBAustin, 281-Max, 282-Rodney283-Karen, 284-Michelle, 285-Stacy286-SvenMarin, 287-CoolingStar9, 288-Billy Jack,289-bbrian, 290-Cris Zimermann, 291-Franx,292-Ramil, 293-JaniceNW, 294-Cathrina Jones 295-Bels, 296-Raman, 297-Jeques,298-NPSG, 299-Anndi, 300-Georganna,301-Jeane Michelle Culp, 302-Sam Chan, 303-Kumowai,304-Michiko, 305-Buchiko, 306-Doodski, 307-Jeevy, 308-Sameera, 309-Annita, 310-Sweet Girl, 311-Jeya Anand